Electron Micrograph of Ebola VirusPhoto Credit: Center for Disease Control
The virus on the left looks innocuous, but it is deadly - causing Ebola hemorrhagic fever, it attacks the endothelial cells that are inside our blood vessels. In advanced infections, Wiki explains the walls begin to leak and the blood platelets are unable to coagulate, eventually leading to hypovolemic shock. (To us non-medical people, this is the catastrophic loss of blood plasma.)
The photograph on the left shows the filamentous composition of the virus, as well as the distinctive "Shepherd's Crook". The CDC tells that the filaments may be 14,000 nanometers in length, a diameter of 80 nanometers, and each virion contains a single molecule of RNA.
The Zaire virus has an average fatality rate of 83 percent. The Reston virus in contrast, is very hazardous to monkeys, but non-pathogenic to humans. There is no treatment for Ebola hemorrhagic fever - only supportive therapy such as fluids and electrolytes.
Ebola Cured in Monkeys - Hope for Humans? explains that researchers developed gene-silencing drugs to defeat infected monkeys. The National Geographic article explains the drugs are based upon small interfering RNA (siRNA). Wiki adds that siRNA are double-stranded molecules capable of suppressing the production of a specific gene. The researchers attacked the L-protein, known to initiate virus replication. With daily injections, they were able to prevent the death of the monkeys from hemorrhagic fever, something never before achieved.
Because Ebola is a plausible terrorist threat, anticipate that governments will sponsor the development of drugs rather than big Pharma. Thankfully there are not sufficient yearly cases to encourage development of anti-Ebola drugs.
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